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Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up

This GHR upregulation sensitises local cells to circulating GH, potentiating GH-induced JAK2/STAT signalling and stimulating collagen matrix synthesis, IGF-1 production, and fibroblast proliferation providing a mechanism through which BPC-157 engages the GH/IGF-1 axis at the tissue level without altering systemic GH secretion

In a study administering Van at 150 mg/kg orally for 19 days, no significant changes were observed in body weight, locomotor activity, motor coordination, spatial navigation, or even mitochondrial markers, such as brain striatum TBARS, nitrite/nitrate levels, glutathione, superoxide dismutase, catalase, or acetylcholinesterase activity

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