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Institutional Review Board Statement All the study procedures were found to be in accordance with the Helsinki Declaration of 1975/83

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In studies lasting 68 weeks, participants taking 412mg daily sometimes showed improved endurance, higher time-to-exhaustion scores, or smaller increases in creatine kinase an enzyme that rises with muscle damage.32 Not all trials find performance benefits, but those that do often include participants with lower baseline antioxidant intake or higher training loads.33 For now, researchers interpret the findings as preliminary evidence that astaxanthin may support recovery in situations where oxidative stress is high.38 Sleep and fatigue Researchers have begun exploring how carotenoid intake might relate to sleep quality

An example is acetamino-phen (paracetamol)-induced hepatotoxicity (Figure 45)