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Some people use microdosing during initial titration to minimize side effects

doi: 10.1186/s12974-021-02252-6 273 RaaschJ.ZellerN.van LooG.MerklerD.MildnerA.ErnyD.et al

Lastly, Ucn 3 mRNA and peptide expression have been identified in the amygdala, lateral septum, ventromedial hypothalamus and paraventricular nucleus of the hypothalamus, basomedial nucleus of the stria terminalis, dorsal raphe nucleus and the area postrema (Lewis et al., 2001