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At the ultrastructural level, irregular and immature elastin fibers and fibers devoid of microfibrils were observed. These findings suggested that both elastic fiber abnormalities and reduced collagen content contribute to the clinical features seen in patients with clEDS. There were no consistent electron microscopy (EM) findings in the ten patients in our cohort who had EM performed

Life-threatening internal bleeding can be a very serious complication in children with thrombocytopenia

Vitamin B12 is water-soluble, meaning excess amounts are excreted through urine, reducing the risk of toxicity