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Nevertheless, in vitro studies on blood vessels have shown that GLP-1RAs inhibit vascular smooth muscle cell proliferation, reduce reactive oxygen species, and increase nitric oxide in vascular endothelial cells [37]

An in vivo test for genotoxicity, generally a test for chromosomal damage using rodent hematopoietic cells, either for micronuclei or for chromosomal aberrations in metaphase cells

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Clinical studies on Semaglutide and breastfeeding are limited, necessitating further studies to understand its potential risks and long-term effects comprehensively