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This work showed the difference between cancer cells that depend on dietary serine and glycine versus de novo serine and glycine synthesis

Fisher RL

Altogether, these examples underscore that despite encouraging experimental results, ferroptosis-targeted drugs face multiple translational bottlenecks, including systemic toxicity, insufficient targeting, metabolic compensation, and biological heterogeneity

However, theaflavins supplementation significantly decreased C11-BODIPY, ROS, and Fe 2+ levels, which further confirmed that theaflavins is an inhibitor of ferroptosis (Fig