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In vivo rat models of OVA-induced asthma demonstrated significant dose-dependent (100 mg/kg and 200 mg/kg) reductions in inflammatory cells in bronchoalveolar lavage fluid (BALF), lung inflammation scores, and NF-B signaling activating promoted by IgE production [57]

Note that the velocity of the DNA methylation reaction (DNMT in Panel C) is also quite stable despite the fact that its substrate, SAM, is undergoing very large fluctuations

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A study reported ionizable lipid NPs loaded with mRNA encoding adenine base editors and sgRNA targeting IDUA mutations, corrected the W392X mutation in the IDUA gene, reducing GAG accumulation and alleviating disease symptoms