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Lasagni, L

Frontiers in neuroendocrinology

A meta-analysis of 87 studies (9,109 participants) found that ASD children had significantly elevated blood levels of oxidative markers such as GSSG, malondialdehyde, and homocysteine, while significantly decreased levels of GSH, total glutathione, the GSH/GSSG ratio, and antioxidant substances such as cysteine, vitamin B9, and vitamin D

It has been found that the endoplasmic reticulum forms a separate cellular compartment from the cytosol, having a relatively oxidized state as compared to the cytosol, and thereby promoting the formation of disulfide links in proteins, which are often necessary for normal activity