melanotic peripheral nerve sheath sarcoma. tumor Malignant peripheral nerve sheath tumor:

Mice lacking Na v 1.3, Na v 1.8, or Na v 1.9, TIIA (antagonists against Na v 1.1, Na v 1.2, and Na v 1.4), and antagonists against different TRPs showed no protective effects on oxaliplatin-induced cold allodynia (Deuis et al., 2013)

The products of red blood cell breakdown, such as hemoglobin, heme and iron, are strong inducers for microglia activation [6]

Further, it stimulates fibroblasts and increases nitric oxide production, aiding in tissue regeneration [3, 9]

Thus, alterations in the Kyn pathway, with an augmentation of neurotoxic components like QA at the expense of neuroprotective derivates like KYNA, seem to have a central role in neuroinflammation in many neuropsychiatric disorders [223]