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placebo over 68 weeks

doi: 10.1016/j.freeradbiomed.2015.12.024 70 ParikhH.PanditaN.KhannaA

In addition to a lack of high-quality evidence of benefit in RLS sufferers, benzodiazepines have well-known side effects that limit their use, including daytime sedation, cognitive impairment, instability and falls, tolerance and dependence, depression, and respiratory failure, particularly in older adults (Walters 2024)