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10.1096/fj.02-0211hyp 66 WangR.-H.ChenP.-R.ChenY.-T.ChenY.-C.ChuY.-H.ChienC.-C.et al (2024a)

Furthermore, the link between astrocytic metabolism and neurodegeneration is gaining traction: during brain aging or degenerative processes, the efficiency of astrocyte-neuron metabolic couplingcritical for glutamate homeostasis via transporters like GLT-1 and GLASTdeclines, leading to reduced glutamate clearance, extracellular accumulation, and NMDA receptor-mediated excitotoxicity, which drives neuronal dysfunction

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