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Experimental studies in diabetic rats demonstrate that ALA (100350 mg/kg/day) improves nerve blood flow (NBF), vascular relaxation, and motor nerve conduction velocity while reducing oxidative markers like thiobarbituric acid reactive substances (TBARS) [76]

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118 Based on structure and function, HDACs are classified into four categories: Class I (HDAC1, 2, 3, 8), which functions primarily in the nucleus to regulate transcription 119,120