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In these studies, the proposed mechanisms for this effect are through the modulation of insulin receptor genes, increasing the insulin/insulin receptor ratio ( The potential effect of NS in promoting insulin release has been studied extensively in T2DM animal models using a combination of streptozotocin (STZ) and nicotinamide or a combination of low-dose STZ with a high-fat diet (HFD)

If heterogeneity was not significant, the fixed-effects model was employed to estimate the overall effect size

The American College of Obstetricians and Gynecologists (ACOG) and the American Diabetes Association (ADA) continue to recommend human insulin as the standard of care in pregnant women with diabetes mellitus and gestational diabetes mellitus (GDM) requiring medical therapy

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