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Efficacy and safety of etrasimod in a phase 2 randomized trial of patients with ulcerative colitis

159161,163,178 In these four studies, a significantly increased risk of developing vitamin B 12 depletion as a result use of acid-lowering medication was identified and data from the two studies evaluating duration of treatment supported the general assumption that long-term use of these drugs is associated with an elevated risk of deficiency of this vitamin, but the results were not conclusive

The combination allows researchers to study multiple supportive pathways at once while maintaining controlled proportions that reduce experimental variability

(IQR 25-49) at PSC diagnosis, were 61% male, and 75% had concurrent inflammatory bowel disease (179 ulcerative colitis, 71 Crohns disease)