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All but the most severe of cases can be successfully managed through lifestyle changes in diet and physical activity alone, although low compliance has encouraged interest in effective therapies, including gastrointestinal surgery (efficacious and long-lasting, but limited in use because of associated risks and costs) and pharmacological interventions

"Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model." Annals of Clinical & Laboratory Science A study indicating the regenerative influence of AOD-9604 on joint cartilage

While foods like grass-fed beef, dairy products and fish supply a good dose of vitamin B12, some people abstain from eating these foods or have a harder time absorbing and actually utilizing this nutrient due to digestive/metabolic limitations

More or less what it says on the tin. But as often happens in peptide research, AOD9604 has turned out to have an entirely different application too in joint health