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Glutamine metabolism in NPC Glutamine is one of the important precursors contributing to de novo nucleotide synthesis, which provides the nitrogen that is required for purine and pyrimidine nucleotide synthesis

Their mechanisms of action, which include the induction of oxidative stress, modulation of apoptosis, inhibition of telomerase, disruption of cell cycle progression, and interference with oncogenic signaling pathways, make them attractive candidates for cancer treatment

"Gamma-glutamyltransferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the plaque"

Type of glutamate receptor and mechanism of action Excitotoxicity was one of the first mechanisms of ischemic cell death to be identified and one of the most intensively studied, with the term excitotoxicity describing the process by which excess glutamate overactivates NMDA receptors (NMDARs) and induces neuronal toxicity (Choi et al., 1988