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By fitting the plasma concentrations to a non-compartmental PK model 34 , we found that the IgG1-REW variants were present at higher concentrations in plasma over time (AUC) compared to WT, had slower clearance, longer mean residence time and lower volume of distribution at steady state (Table S4)

This condition means there are fewer platelets in the blood than usual

Unlike hormones that stay in the body for a long time, peptides bind to the receptor of cells, cause a chemical reaction, then go away

The stomachs, small intestines and the colons were put into 3 ml isotonic sodium chloride solution each and homogenized using a Polytron tissue homogenizer at 12,000 rpm