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Ongoing research into the amylin system extends beyond metabolic physiology and includes investigations into neurological and age-related disorders

Dec 2018;107:48-56

Both preclinical and clinical studies show that circadian disruption aggravates BBB injury, characterized by reduced expression of tight junction proteins (ZO-1, occludin, claudin-5), heightened neuroinflammation (TNF-, IL-1), MMP-9/2mediated extracellular matrix degradation, and HPA axis dysregulation

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