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Figure 3 4.2.2 Macrophages In RA, activity imbalance between pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages elicits inflammation and autoimmunity in the synovium, leading to joint damage ( 2+ can enter mitochondria to maintain mitochondrial homeostasis ( 2+ levels, which promoted the phosphorylation of serum response factor (SRF) and its binding to the vascular endothelial growth factor receptor 2 (VEGFR2) promoter, producing VEGFR2 and thereby promoting inflammatory angiogenesis