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Folate deficiency also predisposes to homocystinuria, which increases the risk of coronary heart disease

[DOI] [PubMed] [Google Scholar] 650

In this report, we found that genetic inactivation of the DAF-12 signaling promoted the production of reactive oxygen species (ROS) during starvation

It significantly reduces renal lipid accumulation by upregulating the expression of CPT enzymes, activates FAO, improves oxidative stress, and protects against mitochondrial dysfunction in the kidneys, thereby alleviating renal injury [139]