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DBD involves the construction of a comprehensive protective network that spans oxidative stressmetabolic stressstructural homeostasisaging regulation through the systematic regulation of the antioxidant pathway (SODSOD2GSH-PxMDA), the restoration of ECM and metabolic homeostasis (MMP1 and PPAR), and the blockade of the senescence fate program (P21)

PMCID: PMC5951015 Li H, Liu X, Zhu Y, Liu Y, Wang Y (2015) Magnolol derivative 002C3 protects brain against ischemia-reperfusion injury via inhibiting apoptosis and autophagy

A quick look at the chart indicates a huge separation between the ME/CFS patients (in red) and the healthy controls (in blue)

The mechanisms underlying these effects likely involve glutathione's role in reducing oxidative stress in metabolic tissues, supporting mitochondrial function and energy production, and modulating inflammatory pathways that affect metabolic regulation