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Figure 3 3.2.2 Pulmonary arterial hypertension Pulmonary arterial hypertension (PAH) is a multifactorial, chronic disease process that results in pulmonary arterial endothelial dysfunction and smooth muscular hypertrophy, leading to right ventricular failure and even death (Humbert et al., 2023

A molar extinction coefficient of 0.041 (mM -1 cm -1 ) was used to determine the CAT activity

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Concurrently, lowered Pol I activity triggers lipidome remodeling towards reduced abundance of damage-prone and lipotoxic phospholipids and fatty acids, with increased Pol I activity conferring the opposite effect on both mitochondrial stress and the lipidome